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CPT symmetry means that a mirror-image of our universe where we reverse all momenta (corresponding to the reversal of time) and with all matter replaced by anti-matter would evolve under exactly the same physical laws.
A nice introduction is this video by Veritasium.
According to the famous CPT theorem the symmetry CPT holds for all physical phenomena under quite reasonable assumptions.
This makes CPT symmetry one of the most important symmetries of modern especially and especially of the standard model of particle physics.